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Jian-Ting Zhang, PhD

Andrew and Peggy Thomson Chair in Hematology/Oncology
Professor of Pharmacology and Toxicology
Director of Graduate Studies

Research Interest 

The major research interests of my laboratory are tumorigenesis, drug discovery, and cancer treatment resistance.

Education 

1983

B.Sc. Biochemistry | Nanjing University | China

1984

Diploma in English | Sun Yet-Sen University | China

1989

Ph.D. Molecular and Cell Biology | State University of New York | Buffalo, New York

Positions 

2007 - present

Andrew and Peggy Thomson Chair in Hematology/Oncology, Indiana University Melvin and Bren Simon Cancer Center   Indianapolis, IN

2005 - 2010

Co-leader, Experimental and Developmental Therapeutics Program, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN

2003- present

Professor, Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN

1998 - present

Member, Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN

1998 - 2009

Walther Investigator, Walther Cancer Institute/Walther Oncology Center, Indianapolis, IN

1998 - 2003

Associate Professor, Department of Pharmacology & Toxicology, Indiana University School of Medicine, Indianapolis, IN

1993 - 1998

Assistant Professor, Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, TX

Editorial Activities 

2010-present

Editor-in-Chief | International Journal of Biochemistry and Molecular Biology

2009-present

Editorial Board Member | Lung Cancer: Targets and Therapy

2009-present

Editorial Board Member | Breast Cancer: Targets and Therapy

2009-present

Editorial Board Member | American Journal of Translational Research

2009-present

Editorial Board Member | Cancer Therapy

2007-present

Editorial Review Board Member | Scientific Journals International

2004-present

Editorial Board Member | Cancer Research on Prevention and Treatment

2004

Guest Editor-in-Chief | Current Medicinal Chemistry: Anticancer Agents

1996-present

Editorial Advisory Panel Member |Molecular Membrane Biology

Honors 

2014

Yao Yuan Award for Excellence, Yao Yuan Academy for Pharma Innovation

2010

Distinguished Alumni Award, Department of Biological Sciences, SUNY at Buffalo

2007-present

Guest Professor | Central South University | Changsha, China

2007

Prostate Cancer Foundation Competitive Award

2005

Michael K. Guest Award for Innovative Research | Walther Cancer Institute | Indiana University School of Medicine

1999

EJCB Most Interesting Paper of the Year

1998-2001

Career Investigator Award | American Lung Association

1998

Eminent Scholar | Indiana University School of Medicine

1995

Outstanding Poster Presentation Award | 86th Annual AACR Conference

1990-1993

Postdoctoral Fellowship | National Cancer Institute of Canada

1983-1984

CUSBEA Fellow

1981

Outstanding Student Award, Nanjing University


Grant Review 

2004 – present

Ad Hoc Member

Florida Biomedical Research Program Scientific Review Group

2003 - 2010

Member

Concept review group, Department of Defense CDMRP-BCRP

2002 - 2010

Member

OC scientific review group, Department of Defense CDMRP-PCRP

2001 - 2014

Member

BC scientific review group, Department of Defense CDMRP-BCRP

2001

Member

OC scientific review group, Department of Defense CDMRP-OCRP

2000-present

Ad Hoc Member

Various study sections, National Institutes of Health

Translational Control

Gene expression is regulated at multiple levels. The two primary regulations of gene expression occur at the level of transcription to produce mRNAs and at the step of translation to produce proteins. Deregulation at any of these steps   

causes abnormal gene expression and, thus, deregulated cell growth and possibly cancer. In eukaryotes, mRNA translation is mainly regulated at the initiation, the rate-limiting step of mRNA translation controlled by many initiation factors (eIFs). We are currently investigating the regulatory role of eIF3 in protein synthesis and oncogenesis.

Drug Resistance/Apoptosis Pathways

Drug resistance is caused by many molecular and cellular mechanisms. One prevalent mechanism is the over-expression of ATP-binding cassette (ABC) transporters, such as MDR1 (ABCB1). These ABC transporters function as membrane pumps that actively efflux a wide variety of anticancer agents out of cells and decrease intracellular accumulation of effective concentrations

of anticancer drugs, resulting in multidrug resistance. Currently, we are studying MRP1 (ABCC1) and BCRP/MXR (ABCG2). Signal transduction pathways in survival and apoptosis are also an important molecular mechanism for cancer cells to survive therapeutic treatments. Currently, we are studying 14-3-3sigma, survivin, and fatty acid synthase and hope to develop these proteins as targets for better future cancer therapies. 

Experimental Therapeutics/Drug Discovery

We established a computation-based, high throughput screening and chemoinformatic laboratory. Using this high throughput screening tool, our goal is to discover small molecule compounds that can be developed into therapeutics to circumvent drug resistance in cancer chemotherapy and for targeted cancer therapies. 

Proteome Profiling and Interactive Proteomics

Proteomic approaches (two-dimensional gel electrophoresis in combination with mass spectrometry) are being used to investigate the proteome in mammalian cells that are under control at the translational level and to identify protein targets that are potentially responsible for drug resistance in cancer chemotherapy. Interactive proteomics using tandem affinity purification (TAP) approach are being applied to identify signaling partners of 14-3-3, survivin, and eIF3.

Selected Publications

 (Display the 10 citations in PubMed)

 

Education

Research

Discovery

Welcome to the Zhang laboratory affiliated with the Department of Pharmacology and Toxicology and the Simon Cancer Center at Indiana University School of Medicine. The major research interest of our laboratory is on tumorigenesis, drug discovery, and cancer treatment resistance. Currently, the laboratory is housed in the new state of the art Joseph Walther Hall (R3) and consists of graduate students, postdoctoral fellows, junior faculty and technical staff. We provide an outstanding opportunity for training of summer undergraduate students, graduate students and postdoctoral fellows in the areas of molecular biology, pharmacology, biochemistry, cancer biology, and bio/chemoinformatics. For more information about the Zhang laboratory, please click icons below.


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Department of Pharmacology and Toxicology | 635 Barnhill Drive, MS A401 | Indianapolis, IN 46202